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Primary lateral sclerosis(PLS),previously undescribed in children,is characterized by a spastic motor deterioration and pathologic demonstration of cortiospinal tract degeneration.We report an infant who, before 12 months of age,developed a progressive motor disease characterized by generalized spasticity.He died at 47 months,and neuropathologic examination revealed only corticospinal tract degeneration.We conclude that this child had typical clinical and pathologic findings for PLS. |
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